The flight distance from Vilo Acuna International Airport (CYO) in Cayo Largo del Sur, Cuba to San Francisco International Airport (SFO) in San Francisco, United States is 4,286 kilometers (2,663 miles / 2,315 nautical miles). The estimated flight time for this route is approximately 6h, flying northwest at a heading of 304°.

This is a long-haul route typically operated by wide-body aircraft such as the Boeing 777 or Airbus A350. Full meal service, in-flight entertainment, and comfort amenities are standard.

This is an international route connecting Cuba with United States. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 04:38 in Cayo Largo del Sur, it's 01:38 in San Francisco. The 3-hour time difference may cause some jet lag. Most travelers adjust within a day or two.

The return flight from San Francisco (SFO) to Cayo Largo del Sur (CYO) follows a heading of 103° (east southeast). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Vilo Acuna International Airport (CYO) and San Francisco International Airport (SFO) detail pages, or use our flight duration calculator to compare other routes.