The flight distance from Key West International Airport (EYW) in Key West, United States to San Francisco International Airport (SFO) in San Francisco, United States is 4,094 kilometers (2,544 miles / 2,211 nautical miles). The estimated flight time for this route is approximately 6h, flying west northwest at a heading of 301°.

This is a long-haul route typically operated by wide-body aircraft such as the Boeing 777 or Airbus A350. Full meal service, in-flight entertainment, and comfort amenities are standard.

This is a domestic route within United States. Both airports operate in the same country, which may simplify travel requirements and documentation. Despite being a domestic route, there is a 3-hour time difference between the two cities.

Time zone information: When it's 04:08 in Key West, it's 01:08 in San Francisco. The 3-hour time difference may cause some jet lag. Most travelers adjust within a day or two.

The return flight from San Francisco (SFO) to Key West (EYW) follows a heading of 99° (east). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Key West International Airport (EYW) and San Francisco International Airport (SFO) detail pages, or use our flight duration calculator to compare other routes.