The flight distance from San Francisco International Airport (SFO) in San Francisco, United States to Ruben Cantu Airport (SYP) in Santiago, Panama is 5,297 kilometers (3,291 miles / 2,860 nautical miles). The estimated flight time for this route is approximately 7h, flying east southeast at a heading of 118°.

This is a long-haul route typically operated by wide-body aircraft such as the Boeing 777 or Airbus A350. Full meal service, in-flight entertainment, and comfort amenities are standard.

This is an international route connecting United States with Panama. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 01:08 in San Francisco, it's 04:08 in Santiago. The 3-hour time difference may cause some jet lag. Most travelers adjust within a day or two.

The return flight from Santiago (SYP) to San Francisco (SFO) follows a heading of 315° (northwest). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the San Francisco International Airport (SFO) and Ruben Cantu Airport (SYP) detail pages, or use our flight duration calculator to compare other routes.