The flight distance from St Louis Lambert International Airport (STL) in St Louis, United States to Ruben Cantu Airport (SYP) in Santiago, Panama is 3,537 kilometers (2,198 miles / 1,910 nautical miles). The estimated flight time for this route is approximately 5h, flying south southeast at a heading of 162°.

This is a medium-haul route that may be operated by either narrow-body or wide-body aircraft depending on demand. Passengers can expect a meal service on most carriers.

This is an international route connecting United States with Panama. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 10:52 in St Louis, it's 11:52 in Santiago.

The return flight from Santiago (SYP) to St Louis (STL) follows a heading of 346° (north northwest). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the St Louis Lambert International Airport (STL) and Ruben Cantu Airport (SYP) detail pages, or use our flight duration calculator to compare other routes.