The flight distance from Denver International Airport (DEN) in Denver, United States to Ruben Cantu Airport (SYP) in Santiago, Panama is 4,247 kilometers (2,639 miles / 2,293 nautical miles). The estimated flight time for this route is approximately 6h, flying southeast at a heading of 140°.

This is a long-haul route typically operated by wide-body aircraft such as the Boeing 777 or Airbus A350. Full meal service, in-flight entertainment, and comfort amenities are standard.

This is an international route connecting United States with Panama. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 03:22 in Denver, it's 05:22 in Santiago.

There is a significant elevation difference of 5,162 feet between the two airports. Ruben Cantu Airport sits lower than Denver International Airport. Travelers arriving at the higher-elevation airport should be aware of potential altitude effects.

The return flight from Santiago (SYP) to Denver (DEN) follows a heading of 330° (north northwest). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Denver International Airport (DEN) and Ruben Cantu Airport (SYP) detail pages, or use our flight duration calculator to compare other routes.